Unraveling the Neuroprotective Role of Magnesium Threonate: A Deep Dive into Cellular Energy, DNA Repair, and Nerve Function
Not every form of this metal works the same way.
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Unraveling the Neuroprotective Role of Magnesium Threonate: A Deep Dive into Cellular Energy, DNA Repair, and Nerve Function
Explore the multifaceted benefits of Magnesium Threonate on cellular energy production, DNA repair, and nerve function and its potential implications for neurodegenerative diseases.
Magnesium, a vital mineral for numerous physiological functions, has recently gained attention for its neuroprotective properties, particularly in the form of magnesium threonate (MgT). MgT, a unique compound capable of crossing the blood-brain barrier, has been shown to enhance brain magnesium levels, thereby influencing various aspects of brain function and health (Slutsky et al., 2010)1.
One of the critical roles of magnesium in the body is its involvement in cellular energy production and storage. Magnesium is a cofactor for ATP, the primary energy currency of cells, and thus plays a crucial role in energy metabolism (Yamanaka et al., 2016)2. In the context of MgT, by increasing brain magnesium levels, MgT could enhance cellular energy metabolism, thereby supporting brain function and health (Liu et al., 2019)3.
Magnesium also plays a role in DNA repair. It is a necessary cofactor for DNA polymerase, an enzyme involved in DNA replication and repair (Cox et al., 2011)[^4^]. By enhancing brain magnesium levels, MgT could support DNA repair processes, which are crucial for maintaining neuronal health and function (Cox et al., 2011)[^4^].
Furthermore, magnesium is a natural antagonist of N-methyl-D-aspartate (NMDA) receptors, a subtype of glutamate receptors. By blocking these receptors, magnesium can help prevent excitotoxicity, a process that can lead to neuronal death if unchecked (Paoletti et al., 2013)[^5^]. Excitotoxicity is thought to play a role in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Therefore, by increasing brain magnesium levels, MgT may help protect against these conditions (Paoletti et al., 2013)[^5^].
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